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Planta Med 2013; 79(08): 697-700
DOI: 10.1055/s-0032-1328399
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii

Tuan-Wu Cao
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
3   University of Chinese Academy of Sciences, Beijing, PR China
,
Chang-An Geng
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Yun-Bao Ma
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Kang He
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Hong-Ling Wang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
3   University of Chinese Academy of Sciences, Beijing, PR China
,
Ning-Jia Zhou
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
3   University of Chinese Academy of Sciences, Beijing, PR China
,
Xue-Mei Zhang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Yan-Duo Tao
2   Research Center for Biological Resources in Qinghai-Tibet Plateau, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, PR China
,
Ji-Jun Chen
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
› Author Affiliations
Further Information

Publication History

received 14 January 2013
revised 25 February 2013

accepted 04 March 2013

Publication Date:
10 April 2013 (online)

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Abstract

Two new xanthones, 8-O-β-D-glucopyranosyl-1-hydroxy-2,3,5-trimethoxyxanthone (1) and 8-O-[β-D-xylopyranosyl-(1 → 6)-β-D-glucopyranosyl]-1-hydroxy-2,3,5-trimethoxyxanthone (2), along with eighteen known xanthones (3–20) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [α]D). All compounds were evaluated for their anti-hepatitis B virus activities on HepG 2.2.15 cells line in vitro, and compounds 3–10 exhibited significant activity inhibiting hepatitis B virus DNA replication with IC50 values from 0.01 mM to 0.13 mM. Compounds 3–5 showed remarkable activity with IC50 values of 0.77, > 0.98, and 0.21 mM for HBsAg, and < 0.62, 0.35, and 0.04 mM for HBeAg, respectively. Meanwhile, the effects of different substitutions on the anti-hepatitis B virus activity of xanthones from S. mussotii were discussed.

Key words

Swertia mussotii - Gentianaceae - xanthones - anti-HBV activity

Supporting Information

 

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