Silver-Catalyzed Direct Addition of Terminal Alkynes to Simple Cyclic Ketones in Water

Abstract

The first catalytic addition of terminal alkynes to simple cyclic ketones in water catalyzed by silver was developed. Cyclic ketones were reacted with terminal alkynes efficiently in water to give the corresponding propargyl alcohols.

Key words

Grignard-type reactions in water - silver catalysis - ­ketone–alkyne addition - propargyl alcohol

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