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Synfacts 2011(7): 0735-0735  
DOI: 10.1055/s-0030-1260647
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Magnesium BINOL Phosphate Catalyzed Phosphination of Imines

Contributor(s): Mark Lautens, Jane Panteleev
G. K. Ingle, Y. Liang, M. Mormino, G. Li, F. R. Fronczek, J. C. Antilla*
Sun Yat-Sen University, Guangzhou, P. R. of China; University of South Florida, Tampa and Louisiana State University, Baton Rouge, USA
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

Considerable effort has been put forth recently towards the synthesis of α-chiral phosphorus-containing compounds (M. Shibasaki et al. Tetrahedron Lett. 1999, 40, 2565; C.-H. Tan et al. Angew. Chem. Int. Ed. 2009, 48, 7387). In this work the authors utilize a BINOL-derived magnesium phosphate catalyst. The magnesium is thought to be significant in the reactivity and stereoinduction since lower yield and ee is observed with a phosphoric acid catalyst obtained after acidic purification.