Saito-Myers Cyclization by Amine-Grafted Mesoporous
Silica

M. Nechab; E. Besson; D. Campolo; P. Perfetti; N. Vanthuyne; E. Bloch; R. Denoyel; M. P. Bertrand

doi:10.1055/s-0030-1260590

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2011(7): 0807-0807
DOI: 10.1055/s-0030-1260590

Polymer-Supported Synthesis

Saito-Myers Cyclization by Amine-Grafted Mesoporous Silica

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Takuma Sato
M. Nechab*, E. Besson*, D. Campolo, P. Perfetti, N. Vanthuyne, E. Bloch, R. Denoyel, M. P. Bertrand*
Aix-Marseille Université, France

Further Information

Publication History

Publication Date:
17 June 2011 (online)

Permissions and Reprints

Significance

The Saito-Myers cyclization of enediyne 1a (99% ee) proceeded in the presence of amine-grafted mesoporous silica (GA-SBA15; 20 mol%) to give 2a and 3a in 21% and 62% yield with 93% and 84% ee, respectively. The grafted silica was reused five times without loss of activity. A plausible reaction pathway is shown.