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Synfacts 2011(7): 0764-0764  
DOI: 10.1055/s-0030-1260499
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

CuI-Catalyzed Trifluoromethylation of Aryl and Vinyl Boronic Acids

Contributor(s): Paul Knochel, Andreas K. Steib
T. Liu, Q. Shen*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

This work discloses a new protocol for the trifluoromethylation of aryl- and alkenylboronic acids under mild conditions in good to excellent yields. The trifluoromethyl group is transferred from 1-trifluoromethyl-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole (Togni’s reagent) under CuI catalysis.