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Synfacts 2010(10): 1160-1160  
DOI: 10.1055/s-0030-1258650
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Chiral Pyrrolidines, Piperidines, and Azepanes

Contributor(s): Mark Lautens, Norman Nicolaus
J. J. Verendel, T. Zhou, J.-Q. Li, A. Paptchikhine, O. Lebedev, P. G. Andersson*
Uppsala University, Sweden
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

Starting from heterocyclic olefins of the general structure 1, which are easily available through ring-closing metathesis, a flexible and enantioselective iridium-catalyzed hydrogenation protocol towards chiral azacyles 2 has been developed. By using P,N-ligands, such as A, B or C, the products could be prepared in high conversions and enantioselectivities.