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Synfacts 2010(4): 0456-0456  
DOI: 10.1055/s-0029-1219598
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Manganese(III)-Mediated Biaryl Synthesis

Contributor(s): Paul Knochel, Tobias Thaler
A. S. Demir*, H. Findik, N. Saygili, N. T. Subasi
Middle East Technical University and Hacettepe University, Ankara, Turkey
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Publication History

Publication Date:
22 March 2010 (online)

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Significance

An efficient procedure for the Mn(OAc)3-mediated synthesis of biaryls and ­heterobiaryls using microwave irradiation has been developed. The reaction of manganese(III) with arylboronic acids leads to the formation of the respective aryl radicals which undergo arylation with benzene or thiophene. Arylboronic acid ­esters were found to be unreactive under the ­reaction conditions.