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Synfacts 2010(4): 0449-0449
DOI: 10.1055/s-0029-1219477
DOI: 10.1055/s-0029-1219477
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Addition of Aromatic Nucleophiles to Isatins
N. V. Hanhan, A. H. Sahin, T. W. Chang, J. C. Fettinger, A. K. Franz*
University of California, Davis, USA
Further Information
Publication History
Publication Date:
22 March 2010 (online)
Significance
This work outlines a Lewis acid catalyzed addition of unactivated electron-rich arene nucleophiles to isatins. A good scope of halogenated isatins is evaluated with generally good yields and ee values. While this reactivity of isatins with nucleophiles is known, this work focuses on the underreported addition of indoles and other heterocyclic nucleophiles.