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Synfacts 2009(10): 1115-1115
DOI: 10.1055/s-0029-1217919
DOI: 10.1055/s-0029-1217919
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
syn-Selective, Three-Component Mannich Reaction in Aqueous Media
C. Mukhopadhyay*, A. Datta, R. J. Butcher
University of Calcutta, Kolkata, India and Howard University, Washington, USA
Further Information
Publication History
Publication Date:
22 September 2009 (online)
Significance
The three-component Mannich reaction is a useful one-pot procedure to obtain synthetically valuable β-amino carbonyl compounds. While procedures for this reaction are well known, typically the use of an organic solvent is necessary. In this study, with water as solvent, a boron chelate complex derived from simple boric acid and glycerol catalyzes the three-component Mannich reaction to provide products in high yields with modest syn selectivities.