Download PDF
Synfacts 2009(10): 1121-1121  
DOI: 10.1055/s-0029-1217849
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Additions to Isatins under Transfer Hydrogenation Conditions

Contributor(s): Mark Lautens, David A. Candito
J. Itoh, S. B. Han, M. J. Krische*
University of Texas at Austin, USA
Further Information

Publication History

Publication Date:
22 September 2009 (online)

    Permissions and Reprints

Significance

Building upon previous work (J. Am. Chem. Soc. 2008, 130, 14891), the authors report the first catalytic enantioselective ­allylation, crotylation and reverse prenylation of activated ketones (1) under transfer hydrogenation conditions. This methodology allows for the use of readily available starting materials and negates the need for the use of stoichiometric organometallic reagents.