Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(6): 0681-0681
DOI: 10.1055/s-0029-1216765
DOI: 10.1055/s-0029-1216765
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Brønsted Acid Catalyzed Enantioselective Three-Component Povarov Reaction
H. Liu, G. Dagousset, G. Masson*, P. Retailleau, J. Zhu*
Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
Further Information
Publication History
Publication Date:
25 May 2009 (online)
Significance
An enantioselective three-component Povarov reaction of aldehydes, anilines, and an enecarbamate is reported. In the presence of chiral phosphoric acid catalyst 1, cis-2,4-disubstituted tetrahydroquinolines 4 are obtained in good yields with excellent enantioselectivity. Both aromatic and aliphatic aldehydes as well as anilines with different electronic properties are suitable substrates.