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Exp Clin Endocrinol Diabetes 1990; 95(2): 263-266
DOI: 10.1055/s-0029-1210962
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Dopamine Receptor in the Streptozotocin-Induced Diabetic Rats

H. Shimizu, Y. Shimomura, M. Takahashi, I. Kobayashi, S. Kobayashi
  • Division of Endocrinology, Department of Medicine, the First Department of Internal Medicine, Gunma University School of Medicine, Maebashi/Japan
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Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

The abnormalities of central dopamine receptors were examined in streptozotocin (STZ, 60 mg/kg)-induced diabetic rats by using apomorphine (APO)-induced changes of locomotor activity. Chronic hyperglycemia (BG >200 mg/dl) suppressed locomotor activity. Decreased locomotor activity was observed in both intact control and diabetic rats after administration of small dose of APO (0.05 mg/kg). On the other hand, diabetic rats showed a lower peak and response than controls, after large dose of APO (0.50 mg/kg) treatment. Moreover, no significant increase of locomotor activity was observed in the diabetic rats, while a significant increase of locomotor activity was observed in the control rats. The present data obtained herein suggest that the disturbances in the central dopaminergic postsynaptic receptors may be related to the decreased locomotor activity in STZ-induced diabetic rats.

Key words

Dopamine receptor - Apomorphine - Locomotor activity - Diabetic rats