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Exp Clin Endocrinol Diabetes 1989; 94(6): 227-232
DOI: 10.1055/s-0029-1210903
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Aromatase Activity in Cultured Ovaries from Fetal and Neonatal Golden Hamsters

N. Terada1 , T. Takada1 , R. Yamamoto2 , H. Taniguchi1 , D. Takatsuka3 , W. Li3 , K. Matsumoto3
  • 1Departments of Experimental Pathology (Head: H. Taniguchi), Osaka University Medical School, Osaka/Japan
  • 2Gastrointestinal Oncology (Head: M. Tatsuta), Osaka University Medical School, Osaka/Japan
  • 3The Center for Adult Diseases (Head: S. Ishigami) Osaka/Japan and Department of Pathology (Head: Prof. K. Matsumoto), Osaka University Medical School, Osaka/Japan
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Publikationsverlauf

1989

Publikationsdatum:
16. Juli 2009 (online)

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Summary

The production of oestrogen from androstenedione by ovaries of hamsters on day 14 of pregnancy and on days 0 and 3 after birth was investigated by culturing these ovaries for 48 h in serum-free medium containing insulin and [3H]androstenedione. Both oestrone and oestradiol-17β were produced in culture of ovaries on day 14 of pregnancy. The production of oestrogen increased about 2-fold in culture of ovaries on days 0 and 3. Dibutyryladenosine 3′:5′-cyclic monophosphate stimulated the oestrogen production by ovaries on day 14 of pregnancy and on days 0 and 3. The present results indicate that the ovaries of fetal and neonatal hamsters have an aromatase activity and that these aromatase activities are responsive to adenosine 3′:5′-cyclic monophosphate.

Key words

Aromatase - Ovary - Golden hamster

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