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Exp Clin Endocrinol Diabetes 1988; 92(6): 349-356
DOI: 10.1055/s-0029-1210825
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Serum Testosterone Levels in Experimental Acute Renal Failure

M. A. Ivić, S. Strahinjić, G. Lajšić-Grubor, V. Stefanović
  • Institute of Nephrology and Hemodialysis, Institute of Physiology1, Faculty of Medicine, Niš/Yugoslavia
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

In dogs made uremic by bilateral ureteral ligation or by uranyl nitrate injection the serum testosterone levels were investigated. In both experimental models of acute renal failure a profound decrease of serum testosterone was found. The relationship between serum iPTH and testosterone levels was also investigated. The significant negative correlation between them was found in both groups of uremic animals, being more pronounced in the uranyl nitrate induced uremia (r = —0.762, p < 0.001) than after bilateral ureteral ligation (r = —0.362, p < 0.05). The simultaneous analysis of serum cortisol levels in both experimental groups as in sham operated controls indicated that stress factors in acute renal failure may also contribute to the testosterone decrease.

Key words

Experimental acute renal failure - Testosterone - Parathyroid hormone - Stress factors