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Exp Clin Endocrinol Diabetes 1988; 92(4): 111-114
DOI: 10.1055/s-0029-1210789
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of Microinjection of Corticosterone into Ventromedial Hypothalamus on Hepatic Acetate Metabolism in Rabbits

K. Seto, H. Saito, H. Kaba, A. Ohri, J. Tanaka, K. Otsuka1 , T. Ozawa1 , M. Kawakami2
  • First Department of Physiology (Chairman: Prof. Dr. K. Seto), Yokohama City University School of Medicine, Yokohama, Japan
  • 1Department of Medicine and Geriatrics (Chairman: Prof. Dr. T. Ozawa), Yokohama City University School of Medicine, Yokohama, Japan
  • 2Kochi Medical School, Nankoku, and Second Department of Physiology (Former Chairman: Prof. Dr. M. Kawakami), Yokohama City University School of Medicine, Yokohama, Japan
Further Information

Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

Corticosterone was injected into the ventromedial hypothalamus (VMH) of rabbits, and changes in hepatic acetate metabolism were studied. The microinjection of corticosterone with seasame oil into the VMH of intact rabbits increased the rates of 14C transfer from 14C-1-acetate into CO2, glucose, ketone bodies, triglyceride, free cholesterol, free fatty acids and phospholipids but decreased those of 14C transfer into cholesterol ester. However, corticosterone injected into the VMH of rabbits with VMH lesions or the parietal cortex of intact rabbits was without effect on the hepatic acetate metabolism. From these results it might be suggested that the VMH is an integral part of the corticosterone-sensitive brain regulator system in the hepatic acetate metabolism.

Key words

Corticosterone - Ventromedial hypothalamus - Acetate metabolism