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Exp Clin Endocrinol Diabetes 1988; 91(3): 369-372
DOI: 10.1055/s-0029-1210772
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Impairment of Sexual Behaviour in Female Rats with Impaired Glucose Tolerance Due to Streptozotocin Treatment of Their Maternal Grandmothers

A. Plagemann, Renate Tönjes, G. Dörner
  • Institute of Experimental Endocrinology, Humboldt University, Medical School (Charité), Berlin, GDR
Further Information

Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

A decreased receptive sexual behaviour was found in female F2-off spring of Streptozotocin-treated maternal grandmothers. These F2-offspring are characterized by decreased glucose tolerance and increased diabetes susceptibility, their metabolic situation being comparable to that of Type II prediabetes. The observed phenomena were associated with permanent hypoplasia of the hypothalamic ventromedial nucleus (HVN). It is hypothesized that there could be a causal relationship between these morphological changes in the HVN and impaired sexual behaviour in female prediabetic rats.

Key words

Diabetes mellitus - Female sexual behaviour - Hypothalamic ventromedial nucleus - Diabetes susceptibility - Maternofoetal transmission

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