Exp Clin Endocrinol Diabetes 1988; 91(1): 1-6
DOI: 10.1055/s-0029-1210714
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Somatomedin-C in Active and Successfully Treated Acromegaly

G. Knappe1 , V. Hesse2 , G. Jahreis2 , W. Rohde3 , Helga Gerl1
  • 1Clinic of Internal Medicine (Director: Prof. Dr. H. Berndt), Humboldt-University (Charité), Berlin/GDR
  • 2Children's Hospital (Director: Prof. Dr. G. Zwacka), Division of Pediatric Endocrinology (Head: Doz. Dr. V. Hesse), Fr.-Schiller-University of Jena
  • 3Institute of Experimental Endocrinology (Director: Prof. Dr. G. Dörner), Humboldt-University (Charité), Berlin/GDR
Further Information

Publication History

1987

Publication Date:
16 July 2009 (online)

Summary

Sm-C concentrations serum were found significantly different in either active acromegaly or following successful treatment with pituitary adenomectomy. Although after normalization of serum GH the Sm-C levels sometimes exceeded the normal range no overlap was found between both groups.

Exceptionally two acromegalic patients showed elevated Sm-C levels in spite of normal GH values. Likewise, a high Sm-C concentration was found in one patient suspective of ectopic GH secretion with only moderately elevate serum GH.

Sm-C determinations are judged as a good adjunct to usual diagnostic methods which in special cases of acromegaly can be even superior to measurements of serum GH.