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Exp Clin Endocrinol Diabetes 1986; 88(6): 360-364
DOI: 10.1055/s-0029-1210618
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Correlation between Mass of Parathyroid Adenoma and Biochemical Indicators of Bone Turnover in Patients with Primary Hyperparathyroidism

P. D. Broulík1 , J. J. Štěpán1 , E. Hradec2 , J. Marek3 , V. Pacovský1
  • 1Third Department of Internal Medicine, Charles University Faculty of Medicine, Prague/Czechoslovakia
  • 2Department of Urology, Charles University Faculty of Medicine, Prague/Czechoslovakia
  • 32nd Department of Pathology, Charles University Faculty of Medicine, Prague/Czechoslovakia
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Publication History

1986

Publication Date:
16 July 2009 (online)

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Summary

We related the weight of the parathyroid adenoma to biochemical variables of bone turnover in 53 patients submitted to parathyroidectomy for primary hyperparathyroidism. There was a positive correlation (r = 0.61, p < 0.01) between iPTH (c-assay) and adenoma weight. No correlations were found between either concentration of circulating iPTH or weight of parathyroid adenoma and severity of skeletal change expressed by total activity of serum alkaline phosphatase and its bone isoenzyme and urinary excretion of hydroxyproline. We conclude that the severity of bone changes in individual patients with primary hyperparathyroidism does not result from the direct tissue effect of a single hormone (parathyroid hormone).

Key Words

Primary hyperparathyroidism - Parathyroid adenoma - iPTH - Serum alkaline phosphatase - Urinary excretion of hydroxyproline

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