Download PDF
Exp Clin Endocrinol Diabetes 1986; 88(6): 303-308
DOI: 10.1055/s-0029-1210610
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Stimulatory Effect of Intracerebroventricularly Administered Dopamine on Vasopressin Release in Rats

T. Iványi1 , F. Laczi1 , G. L. Kovács2 , G. Szabó2 , T. Janáky1 , G. Telegdy2 , F. A. László
  • First Department of Medicine, University Medical School, Szeged/Hungary
  • 1Endocrine Unit (Head: Prof. Dr. F. A. László), University Medical School, Szeged/Hungary
  • 2Department of Pathophysiology (Head: Prof. Dr. G. Telegdy), University Medical School, Szeged/Hungary
Further Information

Publication History

1986

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Experiments were designed to investigate the effects of the intracerebroventricular administration of dopamine (DA) and a DA antagonist (pimozide) on the immunoreactive-vasopressin (IR-VP) contents of the rat magnocellular nuclei (MCN), neurohypophysis (NH) and plasma. The IR-VP levels in the MCN and NH were decreased 5 min after administration of DA in a dose of 20 nmol, but that in the plasma was increased. This effect was not observed after pretreatment with pimozide. Administration of pimozide alone did not affect the IR-VP contents of the MCN, NH or plasma. The results suggest that DA given icv. has a stimulatory effect on VP release from the neurohypophysial system.

Key words

Vasopressin - Dopamine - Magnocellular nuclei - Neurohypophysis

      >