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Exp Clin Endocrinol Diabetes 1986; 88(4): 81-88
DOI: 10.1055/s-0029-1210579
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Pituitary Prolactin Cells in Diabetic Rats Induced by the Injection of Streptozotocin

K. Yamauchi, M. Shiino
  • Department of Anatomy (Head: Prof. Dr. M. Shiino), Wakayama Medical College, Wakayama-shi/Japan
Further Information

Publication History

1985

Publication Date:
16 July 2009 (online)

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Summary

Ultrastructural changes of prolactin (PRL) cells in streptozotocin (STZ)-induced diabetic rats treated with or without insulin were observed by means of conventional and immuno-cytochemical electron microscopic studies. With progress of diabetic state, the number, cellular outline and secretory granules of PRL cells were decreased, and the organella were changed into atrophic. Granule extrusion was frequently observed in PRL cells of diabetic rats but was not seen after the injection of insulin to the diabetic rats in spite of recovering the ultrastructural features of organella in PRL cells.

The above results may suggest that the injection of insulin to diabetic rats stimulates the activity of PRL cells but suppresses the PRL release from PRL cells.

Key words

Prolactin cells - Diabetes - Streptozotocin - Insulin - Rat

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