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Exp Clin Endocrinol Diabetes 1986; 87(1): 63-68
DOI: 10.1055/s-0029-1210524
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of Pharmacological Doses of lopanoic Acid and Thyroxine 5- and 5′-Monodeiodination in Liver and Kidney of the Pig

A. B. Ślebodziński, Ewa Brzezińska-Ślebodzinska, Jadwiga Dudzińska
  • Department of Experimental Pathology of Animals (Head: Prof. Dr. habil. A. B. Ślebodziński), Polish Academy of Sciences, Poznań/Poland
Further Information

Publication History

1985

Publication Date:
16 July 2009 (online)

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Summary

Short-lasting (24—48 h) IOP administration to growing pigs causes the inhibition of both 5- and 5'-thyroxine monodeiodination in the liver and the kidney. After the administration of IOP in vivo or into tissue homogenates, the inhibition of T4 to T3 conversion was stronger than that of T4 to rT3. The inhibitory effect was related to the thyroid hormones concentration in serum and to the age of animals.

Key words

lopanoic acid - Reverse triiodothyronine - Tissue conversion - Triiodothyronine - Thyroxine 5-monodeiodination - Thyroxine 5′-monodeiodination

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