Download PDF
Exp Clin Endocrinol Diabetes 1985; 86(4): 69-73
DOI: 10.1055/s-0029-1210474
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Morphological Changes in Newborn Pigs of Alloxan Diabetic Sows

P. Emmrich, J. Schade, H. Gürtler
  • Institute of Pathology, Departement of Medicine (Director: Prof. Dr. sc. med. A. Hecht) and Department of Biochemistry (Director: Prof. Dr. Dr. E. Kolb) Section of Animal Production and Veterinary Medicine, Leipzig/GDR
Further Information

Publication History

1984

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

We compared morphologically newborn piglets of alloxan diabetic sows with those of control animals. There were no histochemically detectible marked differences between the two groups investigated. In particular no differences in glycogen content of the liver and heart were observed. In all cases the endocrine pancreas was immature with sporadic formation of islet structures. In both groups we were able to demonstrate A- and B-cells immunohistochemically but not a hyperplasia of the B-cell system. The results obtained correlate with the absence of hyperinsulinaemia in newborn pigs of alloxan diabetic sows. We were unable to demonstrate the morphological background or cause of the diminished glucose-induced insulin release in case of alloxan diabetes as was found in 8-day old piglets. Therefore, the changes in newborn pigs of alloxan diabetic sows do not correlate with those in diabetic fetopathy in human beings.

Key words

Alloxan Diabetes - Piglets - Immunohistochemistry

      >