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Exp Clin Endocrinol Diabetes 1984; 84(6): 257-261
DOI: 10.1055/s-0029-1210396
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Sex-specific Concentrations of Plasma Proteins in Rats Determined by Sex Hormones in Perinatal Life

R. Schade, Renate Tönjes1 , G. Dörner1
  • Institute of Pharmacology and Toxicology, Dept. Toxicology, Humboldt-University Medical School (Charité), Berlin/GDR
  • 1Institute of Experimental Endocrinology, Humboldt-University Medical School (Charité), Berlin/GDR
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Publikationsverlauf

1984

Publikationsdatum:
17. Juli 2009 (online)

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Summary

The present investigation examined the relationship between concentrations of plasma proteins in oestrogen-primed adult rats and sex hormone concentrations in neonatal life. α2-acute phase globulin (α2-AP) and female specific protein (FP) were found to be higher in adult females than in adult males. Androgen administration in females on the first day of life declined permanently these protein concentrations, while neonatal castration in males on the first or third day of life resulted in a permanent increase in FP concentration. Both the α2-AP and FP response in adulthood to hormonal stimulation is dependent on the androgen level during a critical neonatal organization period.

Key words

Sex hormones - critical period - α2-acute phase globulin - female specific protein

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