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Exp Clin Endocrinol Diabetes 1983; 82(4): 73-77
DOI: 10.1055/s-0029-1210258
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Long-Term Effects of Early Postnatal Nutrition on Subsequent Body Weight Gain, Emotionality and Learning Behaviour in Male Rats

G. Hinz, K. Hecht, W. Rohde, G. Dörner
  • Institute of Experimental Endocrinology (Director Prof. Dr. G. Dörner) and Department of Neuropathophysiology (Head: Prof. Dr. K. Hecht) of the Clinic of Psychiatry (Director: Prof. Dr. H. Schulze), Humboldt university (Charité) Berlin/GDR
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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

Male rats have been reared as litters of 2 pups (group A) or 12 pups (group B) during the first 3 weeks of life. Males of group A exhibited higher body weights from day 10 to day 430, reached puberty at earlier age and showed lower emotionality as well as diminished learning capability and decreased memory capacity in adulthood as compared to males of group B. Furthermore, adult males of group A developed an increased ratio of insulin to glucose serum concentration at 90 minutes after glucose administration.