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Planta Med 2010; 76(3): 273-275
DOI: 10.1055/s-0029-1186079
Pharmacology
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Evaluation of the Antiangiogenic, Anti-inflammatory, and Antinociceptive Activities of Morin

Hyun-Joo Jung1 , Su-Jung Kim2 , Yun-Seon Song3 , Eun-Hee Park3 , Chang-Jin Lim2
  • 1Brain Korea 21 Project for Medical Science, Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea
  • 2Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University, Chuncheon, Korea
  • 3College of Pharmacy, Sookmyung Women's University, Seoul, Korea
Further Information

Publication History

received May 4, 2009 revised July 25, 2009

accepted July 31, 2009

Publication Date:
11 September 2009 (online)

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Abstract

Morin displayed significant inhibition of chick chorioallantoic membrane (CAM) angiogenesis and was able to increase the endostatin level in human umbilical vein endothelial cells (HUVECs). Morin was shown to contain an in vivo anti-inflammatory activity using a carrageenan-induced air pouch model in mice. Antinociceptive activity of morin was also assessed using an acetic acid-induced writhing test in mice. Collectively, morin possesses antiangiogenic, in vivo anti-inflammatory, and antinociceptive activities.

Key words

morin - antiangiogenic - anti‐inflammatory - antinociceptive - endostatin

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Prof. Eun-Hee Park

College of Pharmacy
Sookmyung Women's University

52 Hyochangwon-gil, Yongsan-gu

Seoul 140-742

Korea

Phone: + 82 27 10 95 65

Fax: + 82 2 32 73 58 47

Email: ehpark@sookmyung.ac.kr

Prof. Chang-Jin Lim

Division of Life Sciences
College of Natural Sciences
Kangwon National University

192-1 Hyoja-2-dong

Chuncheon 200-701

Korea

Phone: + 82 3 32 50 85 14

Fax: + 82 3 32 42 04 59

Email: cjlim@kangwon.ac.kr