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DOI: 10.1055/s-0029-1186026
© Georg Thieme Verlag KG Stuttgart · New York
Lupane-Type Triterpene Glycosides from the Leaves of Acanthopanax koreanum and Their In Vitro Cytotoxicity
Publication History
received May 4, 2009
revised July 8, 2009
accepted July 10, 2009
Publication Date:
10 August 2009 (online)
Abstract
Three new lupane triterpene glycosides, acankoreosides J–L (1–3), were isolated from the leaves of Acanthopanax koreanum. Based on the spectroscopic data, the chemical structures were determined as 3α-hydroxy-20-oxo-30-norlupane-23,28-dioic 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (1); 3α,20,29-trihydroxylupane-23,28-dioic 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (2); and (20S)-3α-hydroxy-29,29-dimethoxylupane-23,28-dioic 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (3). Compounds 1−3 were evaluated for their cytotoxicity and showed moderate activity against four cell lines, A549 (lung), HL-60 (leukemia), MCF-7 (breast), and U937 (leukemia), with IC50 values of 23.4, 36.5, 22.6, and 18.5 µM for 1; 6.8, 18.6, 23.1, and > 100 µM for 2; and 28.9, 21.8, 11.0, and 27.5 µM for 3, respectively.
Key words
Acanthopanax koreanum - Araliaceae - lupane glycoside - acankoreoside - in vitro cytotoxic activity
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Prof. Dr. Young Ho Kim
College of Pharmacy
Chungnam National University
305-764 Daejeon
Korea
Phone: + 82 4 28 21 59 33
Fax: + 82 4 28 23 65 66
Email: yhk@cnu.ac.kr