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Horm Metab Res 1970; 2(1): 21-27
DOI: 10.1055/s-0028-1095122
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© Georg Thieme Verlag KG Stuttgart · New York

Metabolic Effects of γ-Guanidinobutyramide
II. In Vitro Studies on Muscle, Adipose Tissue and the-Endocrine Pancreas[*]

W. J. Malaisse1 , I. M. Mandelbaum2 , J. R. M. Franckson2
  • 1Laboratory of Experimental Medicine, Brussels University, Brussels, Belgium
  • 2Department of Clinical Chemistry, Brussels University, Brussels, Belgium
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

In vitro, γ-guanidinobutyramide (HL523) stimulates in muscle glucose uptake, glycogenosis, glycolysis and glucose oxidation; in adipose tissue glucose oxidation; and insulin secretion in pieces of pancreatic tissue incubated at physiological glucose concentration. These metabolic effects of HL523 can account for its hypoglycemic action in vivo.

Key words

γ-Guanidinobutyramide - Glucose Metabolism - Glycogen - Insulin Secretion - Diaphragm - Adipose Tissue

1 This work was supported in part by a grant from the Fonds National de la Recherche Scientifique (W.J.M.), and by the association contract Euratom-Universities of Pisa and Brussels (026-63-04 BIAC).

1 This work was supported in part by a grant from the Fonds National de la Recherche Scientifique (W.J.M.), and by the association contract Euratom-Universities of Pisa and Brussels (026-63-04 BIAC).