Download PDF
Horm Metab Res 1970; 2(3): 131-134
DOI: 10.1055/s-0028-1095101
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Insulin Stimulation by Secretin in Diabetics.
Effects of Repeated and of Varied Doses

I.  Hindberg , B.  Enk , I.  Persson
  • Medical Department E and the Central Laboratory, Frederiksberg Hospital, Copenhagen, Denmark
Further Information

Publication History

Publication Date:
08 January 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

A rapid, high increase in the serum insulin level was noted in diabetics after i.v. injection of 75 units of pure secretin (Jorpes). Repeated injection after 15 minutes provoked a smaller, but still significant, insulin release. The insulin concentration returned approximately to the fasting level 15 minutes after each injection. Doubling the secretin doses did not augment the responses.

The effect of the second dose of secretin constitutes a difference from the results of in vitro experiments.

Key words

Secretin - Insulin - Diabetics - Pancreas - Intestinal hormones