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Horm Metab Res 1973; 5(4): 261-266
DOI: 10.1055/s-0028-1093943
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© Georg Thieme Verlag KG Stuttgart · New York

Evidence for LH and FSH Binding Protein(s) in Human and Rat Serum[*]

H.  Rajaniemi , T.  Vanha-Perttula [**]
  • Department of Anatomy, University of Turku, 20520 Turku, Finland
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Publication Date:
07 January 2009 (online)

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Abstract

The binding of 125I-labeled LH and FSH in the rat and human serum proteins was studied by electrophoresis on Oxoid membrane. Both hormones showed a change in their electrophoretic mobility when incubated with serum. This was interpreted as an indication of hormone binding to serum protein(s). Qualitatively the effect was similar in the rat serum as well as in sera from normal men and women including pregnancy and postmenopause. The fetal serum, however, was deficient of this binding activity.

In immunodiffusion and Immunoelectrophoresis new precipitation lines appeared after the incubation of LH and FSH with the sera. It was concluded that both gonadotrophins may bind to the same serum proteins. The meaning of this binding may be related to the maintenance of the hormonal homeostasis.

Key words

Luteinizing Hormone - Follicle-Stimulating Hormone - Protein Binding - Rat - Man

1 This work has been supported by grants from The Finnish Medical Foundation and The Sigrid Juselius Foundation

1 This work has been supported by grants from The Finnish Medical Foundation and The Sigrid Juselius Foundation

2 **Present address: Department of Anatomy, University of Kuopio, 70101 Kuopio 10 (Finland)