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Horm Metab Res 1973; 5(4): 258-261
DOI: 10.1055/s-0028-1093942
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© Georg Thieme Verlag KG Stuttgart · New York

Biological ACTH Activity of Lipid Mobilizing Peptide Fractions from Hog Pituitaries[*]

O. A. Müller , W.  Pister , P.  Schwandt , P. C. Scriba , P.  Weisweiler
  • I. and II. Medizinische Klinik der Universität München, München, Germany
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

The ACTH activity of lipid mobilizing fractions from porcine pituitaries was determined using a sensitive bioassay for ACTH. For different lipolytic fractions between 12 and 27 ng ACTH per 100 µg were found. However, no lipolytic response was obtained in the rabbit with approximately 2,5 µg ACTH. It was therefore concluded, that ACTH does not contribute significantly to the lipolytic activity of our lipotropin preparations. The preparations appear however to contain a minimal ACTH contamination, which was lost upon storage of solutions at -16°C with preservation of the lipolytic activity.

Key words

Hog Pituitaries - Lipotropin - ACTH - Lipolysis - ACTH-Bioassay

1 Supported by the Deutsche Forschungsgemeinschaft (SFB 51)

1 Supported by the Deutsche Forschungsgemeinschaft (SFB 51)