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DOI: 10.1055/s-0028-1093940
© Georg Thieme Verlag KG Stuttgart · New York
The Effect of Secretin on Pancreatic Glucoregulatory Hormones in Man[*]
Publication History
Publication Date:
07 January 2009 (online)
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Abstract
Secretin was given intravenously to four normal men as a 150 U pharmacologic pulse. To an additional four men, during hyperglycemia, secretin was administered as a 5 U pulse with an infusion of 1.2 U per minute for 30 minutes, a rate shown to produce plasma secretin levels similar to those found after oral glucose load. Although insulin increased an average of 7 and 12 fold during the respective infusions, secretin did not significantly alter glucagon levels. These data suggest that, in humans, secretin influences glucose utilization by enhancing insulin release without producing a concomitant change in glucagon.
Key words
Secretin - Glucagon - Insulin - Glucose
1 This investigation was supported by USPHS Research Grant AM-13457, Program Project Grant HD-04872 and a research award from the American Diabetes Association. A portion of this work was conducted through the Clinical Research Center Facility of the University of Washington supported by the NIH (grant RR-37). Dr. Dudl is a recipient of USPHS Special Research Fellowship 1-F03-HD 51572
1 This investigation was supported by USPHS Research Grant AM-13457, Program Project Grant HD-04872 and a research award from the American Diabetes Association. A portion of this work was conducted through the Clinical Research Center Facility of the University of Washington supported by the NIH (grant RR-37). Dr. Dudl is a recipient of USPHS Special Research Fellowship 1-F03-HD 51572