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Horm Metab Res 1975; 7(5): 400-402
DOI: 10.1055/s-0028-1093736
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© Georg Thieme Verlag KG Stuttgart · New York

Evidence for the D-Cell of the Pancreas Secreting Somatostatin

L.  Orci , D.  Baetens , M. P. Dubois , C.  Rufener
  • Institute of Histology and Embryology, University of Geneva Medical School, Geneva, Switzerland and
    I.N.R.A., Station de Physiologie de la Reproduction, Nouzilly, France
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

By immunofluorescence, somatostatin-, glucagon- and insulin-containing cells are localized in serial sections of the pigeon pancreas. The distribution of the somatostatin immunofluorescent-cells corresponds to that of the D-cells (A1-cells), which are particularly numerous in this animal species. This observation, coupled with the finding of D, A and B-cells at the ultrastructural level, indicates that the D-cell is responsible for the secretion of somatostatin.

Key words

Somatostatin - D-Cell - Endocrine Pancreas - Pigeon - Immunofluorescence - Electron Microscopy