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Horm Metab Res 1975; 7(6): 508-511
DOI: 10.1055/s-0028-1093714
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© Georg Thieme Verlag KG Stuttgart · New York

Extended Somatostatin Treatment of a Patient with Bleeding Ulcer

P.  Mattes , S.  Raptis , Th.  Heil , H.  Rasche , R.  Scheck
  • Department of General Surgery, Center for Operative Medicine and Departments of Endocrinology and Metabolism, and Hematology, Center for Internal Medicine and Pediatrics, University of Ulm, Germany
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

The results of a 67hour cyclic somatostatin continuous infusion in a patient with a bleeding ulcer are reported. The subject was a 65 year old male with very heavy gastrointestinal bleeding on the 9th postoperative day following a high BI-resection. Endoscopy revealed the bleeding to be caused by two residual ulcers in the area of the anastomosis. Somatostatin treatment led to an immediate cessation of the bleeding after 1 hour. Gastric secretion as well as gastrin, insulin and growth hormone levels were significantly inhibited by somatostatin. Endoscopy at the end of the treatment period showed two ulcers in the process of healing. The raised blood glucose levels caused by somatostatin were easily controlled with max. 14 IU cristalline insulin daily. Except for dryness in the mouth, no adverse side effects were apparent. There was no evidence from laboratory investigations of hemostatic defects or bleeding tendency in the patient.

Key words

Somatostatin - Peptic Ulcer - Bleeding