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Horm Metab Res 1975; 7(6): 481-484
DOI: 10.1055/s-0028-1093708
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© Georg Thieme Verlag KG Stuttgart · New York

The Lipoprotein Lipase Activity of Brown Adipose Tissue during Early Post-Natal Development of the Normal and Hypothyroid Rat.

P.  Hemon , D.  Ricquier , G.  Mory
  • Laboratoire de Physiologie comparée de l'Université Pierre et Marie Curie (Paris VI ), Paris France.
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Publication Date:
23 December 2008 (online)

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Abstract

The heparin-releasable LP lipase activity of BAT (brown adipose tissue), and the TG (triglyceride) content of plasma were determined in normal and hypothyroid rats during early post-natal development. The TG content of plasma increased sharply after the onset of suckling and decreased during the weaning period in normal rats, while it stayed at a high level in hypothyroid rats. LP lipase activity was maximal during the perinatal period and decreased later, being practically undetectable in one month old control animals; in contrast, LP lipase activity was still present in cretin rats at this age.

The effects of several forms of treatment were also tested in weaned rats: a high-fat diet was not able to maintain the high LP lipase activity of suckling rats, but the activity was high if the animals were bred at a cold temperature. Thyroxine injections had no effect.

These results are discussed in terms of the possible factors regulating the LP lipase activity in BAT.

Key words

Brown Adipose Tissue - LP Lipase Activity - Post-Natal Development - Hypothyroidism - Cold Response