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Synfacts 2009(3): 0289-0289  
DOI: 10.1055/s-0028-1087779
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Intermolecular Hydroacylation

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
J. D. Osborne, H. E. Randell-Sly, G. S. Currie, A. R. Cowley, M. C. Willis*
University of Oxford, University of Bath and AstraZeneca, Macclesfield, UK
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

The authors reported previously the enantioselective hydroacylation of alkenes and alkynes but experienced problems with 1,1- or 1,2-disubstituted alkenes. Reasoning 1,3-disubstituted allenes could fill this void as the authors found a catalytic system that allowed access the nonconjugated enones. A simple rhodium phosphine system was found to provide the hydroacylation of allenes to β-S-substituted aromatic aldehydes.