Mild Pd-Catalyzed Amination of Aryl and Heteroaryl Tosylates

Significance

This important article demonstrates that (hetero)aryl tosylates can be efficiently converted in Pd-catalyzed amination reactions. Tosylates can be easily accessed from the corresponding phenols and are unlike triflates less expensive to prepare and give stable, crystalline solids. The reaction tolerates sensitive functionalities and proceeds even with electron-rich and sterically hindered substrates.