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Synfacts 2009(1): 0083-0083  
DOI: 10.1055/s-0028-1087456
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

α-Arylation of Aldehydes Using Electron-Rich Aryl Halides

Contributor(s): Paul Knochel, Tobias Thaler
R. Martin, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

With this improved protocol for the Pd-catalyzed α-arylation of aldehydes, the scope of the reaction could be efficiently extended to the use of the less reactive electron-rich aryl bromides and aryl chlorides. The reaction is highly general and proceeds for both linear and α-branched aldehydes.