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Synfacts 2009(1): 0070-0070  
DOI: 10.1055/s-0028-1087281
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Counteranion-Induced Asymmetric Hydrogenation of Imines

Contributor(s): Mark Lautens, Praew Thansandote
C. Li, C. Wang, B. Villa-Marcos, J. Xiao*
The University of Liverpool, UK
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

An Ir-catalyzed asymmetric hydrogenation of acyclic imines is described. Several of the substrates examined have been reported to give lower enantioselectivities under different ­hydrogenation conditions (S. Hoffmann, A. M. Seayad, B. List Angew. Chem. Int. Ed. 2005, 44, 7424). A chiral phosphate counteranion is used for enantioselective induction. Excellent yields and enantioselectivities are seen for a broad range of N-aryl imines.