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Synfacts 2009(1): 0006-0006  
DOI: 10.1055/s-0028-1087234
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Leustroducsin B

Contributor(s): Philip Kocienski, Arndt W. Schmidt
K. Miyashita*, T. Tsunemi, T. Hosokawa, M. Ikejiri, T. Imanashi*
Osaka University and Osaka Ohtani University, Japan
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

The leustroducsins show various biological activities, including antimetastatic properties. A convergent approach to leustroducsin B is reported, based on a synthesis of the structurally related fostriecin by the same group. The three major fragments A, B and F were synthesized from known compounds.