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Synfacts 2008(11): 1200-1200  
DOI: 10.1055/s-0028-1083459
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cu(II)-Mediated Cyclopropylation of Amides and Azoles

Contributor(s): Paul Knochel, Andrei Gavryushin
S. Bénard, L. Neuville, J. Zhu*
Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

The development of methods for attaching an N-cyclopropyl unit in a molecule is of great importance for current medicinal chemistry. Herein, a simple, convenient and quite versatile method for cyclopropanation of various azoles as well as amides and sulfonamides is described. It uses readily available inexpensive reagents and does not require special precautions like inert atmosphere. The process should be easy to scale up and therefore may find useful applications in industry.