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Synfacts 2008(11): 1201-1201  
DOI: 10.1055/s-0028-1083458
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient Sonogashira Coupling of Aryl Chlorides

Contributor(s): Paul Knochel, Andrei Gavryushin
H. Huang, H. Liu*, H. Jiang, K. Chen
Shanghai Institute of Materia Medica, P. R. of China
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

The Sonogashira reaction of aryl chlorides is a challenging process with only limited success that has so far been achieved. The present method describes a fast (in minutes) and convenient microwave-assisted coupling of aryl chlorides, including electron-rich substrates, such as terminal alkynes, which can be especially useful for the synthesis of compounds libraries. Alkenyl chlorides are also suitable substrates under the described reaction conditions.