Cu(I)-Promoted Synthesis of Chloromethyl Ketones from CCl₃-Carbinols

Significance

Chloromethyl ketones are important synthetic intermediates, especially for the preparation of heterocycles. The present work describes a very simple, versatile, efficient and inexpensive protocol for the preparation of chloro­methyl ketones starting from readily available trichlormethyl carbinols. The chloromethyl ketones, difficult to prepare by other routes, can be easily synthesized. The method should be easy to scale up and suitable for industrial use.