New Chiral Diene Ligands for Iridium-Catalyzed [3+2] Annulation

Significance

The authors have developed new C ₂-symmetric chiral diene ligands bearing a tetrafluorobenzobarrelene via a [4+2] cycloaddition of tetrafluorobenzyne. The diene ligands realized the iridium-catalyzed enantioselective [3+2] annulation of 1,3-dienes with 2-formylphenylboron ­reagents to afford 1-indanol derivatives in high yields and with high enantioselectivities. The required chiral ligand was prepared and additionally synthesized using a chiral column.