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Synfacts 2008(11): 1193-1193  
DOI: 10.1055/s-0028-1083425
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

1,4-Addition of Alkyl and Aryl-Aluminums to Cyclic Enones

Contributor(s): Mark Lautens, Jane Panteleev
T. L. May, M. K. Brown, A. H. Hoveyda*
Boston College, Chestnut Hill, USA
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

The authors report the 1,4-addition of organoaluminum reagents to unactivated β-substituted cyclopentenones, which previously comprised a difficult set of substrates for this reaction. A moderate range of compounds bearing quaternary centers in high enantiomeric purity is produced.