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Synlett
DOI: 10.1055/a-2593-6446
letter

Nucleophilic Additions of Organolithium Reagents to Heterocyclic Aldimines

Justin Baek
1   Chemistry and Biochemistry, College of Charleston, Charleston, United States
,
Walker Hoisington
1   Chemistry and Biochemistry, College of Charleston, Charleston, United States
,
Evelyn Galgano
1   Chemistry and Biochemistry, College of Charleston, Charleston, United States
,
Ethan Schneider
1   Chemistry and Biochemistry, College of Charleston, Charleston, United States
,
Timothy J. Barker
1   Chemistry and Biochemistry, College of Charleston, Charleston, United States
› Author AffiliationsSupported by: National Institute of General Medical Sciences 8 P20 GM103499
Supported by: National Center for Research Resources 5 P20 RR016461
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The addition of alkyllithium reagents to heterocyclic aldimines is described. This method is a straightforward two-step procedure from the starting aldehyde and amine with one purification. The ability to use unprotected indole carboxaldehydes as substrates is a key feature of this method that make it an attractive way to synthesize the corresponding amine products.



Publication History

Received: 07 March 2025

Accepted after revision: 23 April 2025

Accepted Manuscript online:
23 April 2025

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