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Synlett
DOI: 10.1055/a-2589-5229
synpacts

One Carbon at a Time: Unlocking Iterative Carboxylic Acid Homologation

Emilie Wheatley
1   GSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Nottingham, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN6123)
,
Mattia Silvi 
1   GSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Nottingham, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN6123)
› Author AffiliationsSupported by: EPSRC EP/V006401/1
Supported by: UK Research and Innovation EP/X042766/1
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The development of a direct and iterative protocol for carboxylic acid homologation has constituted a long-standing challenge in synthesis. We recently disclosed an efficient and practical strategy for the homologation of unmodified carboxylic acids, which exploits the visible light photoredox reactivity of nitroethylene. This Synpacts article aims to provide an overview of the motivation behind the design of the homologation strategy, and the key insights of its development.



Publication History

Received: 14 March 2025

Accepted after revision: 16 April 2025

Accepted Manuscript online:
16 April 2025

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