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Planta Med
DOI: 10.1055/a-2565-6197
Original Papers

Angelicone Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota

Chengwei Ruan
1   Department of Anal-Rectal, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Weiwei Gao
1   Department of Anal-Rectal, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Guoguo Wang
2   Department of Nursing, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Wenting Fan
3   Department of Clinical Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Weifeng Zhang
1   Department of Anal-Rectal, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Shuang Tao
1   Department of Anal-Rectal, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Zheng Wu
1   Department of Anal-Rectal, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
› Author AffiliationsThis project was financially supported by the science and technology project of Xuzhou City (KC23280).
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Abstract

Ulcerative colitis (UC) is a persistent, periodically reoccurring inflammatory condition that impacts the gastrointestinal tract. Angelicone, a principal compound extracted from Angelica sinensis, may offer a potential alternative therapeutic approach for UC through the downregulation of inflammatory mediators. Nonetheless, the pharmacological impacts and molecular pathways of angelicone in UC management, particularly in relation to gut microbiota, remain unexplored. The current study scrutinized the modifications in gut microbiota in mice afflicted with UC, induced by 3% dextran sodium sulfate (DSS), utilizing 16S rRNA sequencing. The study demonstrated that angelicone substantially enhanced clinical indices, mitigated colonic damage, decreased cytokine levels, and reestablished the integrity of the intestinal epithelial barrier in UC mice. Furthermore, we discerned distinct bacterial genera that were responsive to angelicone treatment. Importantly, angelicone augmented the abundance of gut microbiota and partially reinstated the disrupted intestinal microbial composition, inclusive of the phyla Proteobacteria, Firmicutes, and Bacteroidetes. To summarize, our research offers novel perspectives into the intervention mechanisms of angelicone in the treatment of UC.

Keywords

angelicone - gut microbiota - ulcerative colitis - dextran sodium sulfate - 16S rRNA - Angelica sinensis - Apiaceae

Supporting Information



Publication History

Received: 14 August 2024

Accepted after revision: 24 March 2025

Accepted Manuscript online:
24 March 2025

Article published online:
17 April 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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