Subscribe to RSS
DOI: 10.1055/a-2511-9769
Venookklusive erektile Dysfunktion: aktuelle Übersicht und klinischer Leitfaden
Venoocclusive erectile dysfunction: up-to-date review and clinical guide
Zusammenfassung
Hintergrund
Erektile Dysfunktion (ED) ist einer der häufigsten Vorstellungsgründe in der urologischen Praxis. Trotz des wesentlichen Fortschritts im Verständnis der Pathophysiologie der ED bleiben noch einige vaskuläre Ursachen, wo diagnostische und therapeutische Maßnahmen nicht einheitlich sind.
Fragestellung
Was ist der richtige Weg bei Verdacht auf eine venöse Leckage? Was ist der Stellenwert der venösen ligierenden Operationen und der radiologischen Interventionen?
Material und Methoden
Die narrative Literaturübersicht der vorhandenen Quellen hinsichtlich der venösen kavernösen Insuffizienz.
Ergebnisse
Die Ursachen der kavernösen venösen Insuffizienz sind heterogen. Die effektivste Behandlunsgmethode ist Implantation einer Schwellkörperprothese. Die venösen ligierenden Operationen oder radiologischen Interventionen sind keine verlässliche Therapieoption aufgrund des Rezidivrisikos.
Schlussfolgerungen
Die Patienten mit einer kavernösen venösen Insuffizienz sind Kandidaten für die Implantation einer Schwellkörperprothese. Die Gefäßinterventionen bei dieser Patientengruppe können im Rahmen von klinischen Studien durchgeführt werden.
Abstract
Background
Erectile dysfunction (ED) is one of the most frequently reasons for patient presentation in the urological practice. Despite fundamental progress in the understanding of ED pathophysiology, there are some vascular forms of ED where the diagnostic and therapeutic pathway is not clear (cavernous venous insufficiency).
Objectives
What is the right procedure when venous leakage is suspected? How important are venous ligation surgery and radiological interventions?
Materials and methods
Narrative literature review of the available sources on cavernous venous insufficiency.
Results
The reasons for venous cavernous insufficiency are heterogenous. The most effective and reliable therapy option is penile prothesis implantation. Venous ligation surgery or radiological interventions are not reliable options, because of the risk of recurrence.
Conclusions
Patients with venous cavernous insufficiency are candidates for penile prosthesis implantation. In this group of patients, vascular interventions may be performed as options for clinical study.
-
Die Möglichkeit einer venookklusiven Insuffizienz sollte immer im Rahmen der Diagnostik und Therapie bei ED beachtet werden.
-
Die Patienten mit einer VOED sollten über alle diagnostischen und therapeutischen Optionen aufgeklärt werden.
-
Die aktuelle Datenlage und Effizienz der therapeutischen Optionen sollte den Patienten so früh wie möglich erläutert werden, um die unrealistischen Erwartungen zu vermeiden.
-
Bei Bedarf sollte gleichzeitig mit der Diagnostik und Therapie eine sexualmedizinische psychologische Anbindung angeboten werden (CAVE: keine Kostenübernahme durch GKV).
-
Venookklusive therapeutische Interventionen werden nicht empfohlen.
Schlüsselwörter
erektile Dysfunktion - venookklusive erektile Dysfunktion - kavernöse venöse Insuffizienz - penile venöse Operationen - penile GefäßinterventionenKeywords
erectile dysfunction - venoocclusive erectile dysfunction - cavernous venous insufficiency - penile venous surgery - penile vascular surgeryPublication History
Received: 13 September 2024
Accepted after revision: 04 January 2025
Article published online:
04 February 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
-
Literatur
- 1 Sexuelle Probleme unter Männern in Deutschland 2020 | Statista. Accessed October 16, 2023 at: https://de.statista.com/statistik/daten/studie/1177722/umfrage/sexuelle-probleme-unter-maennern-in-deutschland-nach-alter/
- 2 Eid JF, Nehra A, Andersson KE. et al. First International Conference on the Management of Erectile Dysfunction Overview consensus statement. Int J Impot Res 2000; 12: 2-5
- 3 Gratzke C, Angulo J, Chitaley K. et al. Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med 2010; 7: 445-475
- 4 Nguyen HMT, Gabrielson AT, Hellstrom WJG. Erectile Dysfunction in Young Men – A Review of the Prevalence and Risk Factors. Sex Med Rev 2017; 5: 508-520
- 5 Allaire E, Sussman H, Zugail AS. et al. Erectile Dysfunction Resistant to Medical Treatment Caused by Cavernovenous Leakage: An Innovative Surgical Approach Combining Pre-operative Work Up, Embolisation, and Open Surgery. European Journal of Vascular and Endovascular Surgery 2021; 61: 510-517
- 6 Hsu G-L, Hsieh C-H, Wen H-S. et al. Penile Venous Anatomy: An Additional Description and Its Clinical Implication. J Androl 2003; 24: 921-927
- 7 Chen S-C, Hsieh C-H, Hsu G-L. et al. The progression of the penile vein: could it be recurrent?. J Androl 2005; 26: 53-60
- 8 Partin AW, Peters CA, Kavoussi LR. et al. Campbell-Walsh-Wein Urology, Twelfth Edition. Philadelphia: Elsevier; 2020
- 9 Hsu G-L, Hung Y-P, Tsai M-H. et al. Penile Veins Are the Principal Component in Erectile Rigidity: A Study of Penile Venous Stripping on Defrosted Human Cadavers. J Androl 2012; 33: 1176-1185
- 10 Lue TF. The mechanism of penile erection in the monkey. Semin Urol 1986; 4: 217-224
- 11 Pathak RA, Rawal B, Li Z. et al. Sexual Function/Infertility Novel Evidence-Based Classification of Cavernous Venous Occlusive Disease. J Urol 2016; 196: 1223-1227
- 12 Yang Z, Zhou Z, Wang X. et al. Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 ameliorates diabetes mellitus-related erectile dysfunction in rats. Urology 2013; 81: 464.e11-6
- 13 Lue TF. Surgery for crural venous leakage. Urology 1999; 54: 739-741
- 14 Gonzalez-Cadavid NF. Mechanisms of Penile Fibrosis. J Sex Med 2009; 6: 353-362
- 15 Kendirci M, Nowfar S, Gur S. et al. The relationship between the type of penile abnormality and penile vascular status in patients with peyronie’s disease. J Urol 2005; 174: 632-635
- 16 Flores S, Choi J, Alex B. et al. Erectile dysfunction after plaque incision and grafting: short-term assessment of incidence and predictors. J Sex Med 2011; 8: 2031-2037
- 17 Lopez JA, Jarow JP. Penile vascular evaluation of men with Peyronie’s disease. J Urol 1993; 149: 53-55
- 18 Gholami SS, Gonzalez-Cadavid NF, Lin C-S. et al. Peyronie’s disease: a review. J Urol 2003; 169: 1234-1241
- 19 Bekos A, Arvaniti M, Hatzimouratidis K. et al. The natural history of Peyronie’s disease: an ultrasonography-based study. Eur Urol 2008; 53: 644-650
- 20 Lumen N, Campos-Juanatey F, Greenwell T. et al. European Association of Urology Guidelines on Urethral Stricture Disease (Part 1): Management of Male Urethral Stricture Disease. Eur Urol 2021; 80: 190-200
- 21 Pal DK, Biswal DK, Ghosh B. Outcome and erectile function following treatment of priapism: An institutional experience. Urol Ann 2016; 8: 46-50
- 22 Ortaç M, Çevik G, Akdere H. et al. Anatomic and Functional Outcome Following Distal Shunt and Tunneling for Treatment İschemic Priapism: A Single-Center Experience. J Sex Med 2019; 16: 1290-1296
- 23 Kominsky H, Beebe S, Shah N. et al. Surgical reconstruction for penile fracture: a systematic review. Int J Impot Res 2020; 32: 75-80
- 24 Sikka SC, Hellstrom WJG, Brock G. et al. Standardization of Vascular Assessment of Erectile Dysfunction. J Sex Med 2013; 10: 120-129
- 25 Flores JM, West M, Mulhall JP. Efficient use of penile Doppler ultrasound for investigating men with erectile dysfunction. J Sex Med 2024; 21: 734-739
- 26 Hsu GL, Chang YK, Chiang IN. et al. A case report of right cardiac ventricle perforation by uncontrolled embolization coil inserted for treating penile veno-occlusive dysfunction. Urol Case Rep 2022; 44: 102166
- 27 Di Serafino M, Pucci L, Iacobellis F. et al. MRI-Cavernosography: A New Diagnostic Tool for Erectile Dysfunction Due to Venous Leakage: A Diagnostic Chance. Diagnostics 2023; 13: 2178
- 28 Chang K-S, Chung C-H, Chang Y-K. et al. Coil Embolization Is Not Justified for Treating Patients with Veno-Occlusive Dysfunction: Case Series and Narrative Literature Review. Life 2024; 14: 911
- 29 Hellstrom WJG, Montague DK, Moncada I. et al. Implants, mechanical devices, and vascular surgery for erectile dysfunction. J Sex Med 2010; 7: 501-523
- 30 Chang K-S, Chang Y-K, Chung C-H. et al. Emergent Penile Venous Stripping for Treating Adolescent Impotence. Life 2024; 14: 762
- 31 Doppalapudi SK, Wajswol E, Shukla PA. et al. Endovascular Therapy for Vasculogenic Erectile Dysfunction: A Systematic Review and Meta-Analysis of Arterial and Venous Therapies. Journal of Vascular and Interventional Radiology 2019; 30: 1251-1258.e2
- 32 Gilbert P, Sparwasser C, Beckert R. et al. Venous surgery in erectile dysfunction. The role of dorsal-penile-vein ligation and spongiosolysis for impotence. Urol Int 1992; 49: 40-47
- 33 Çayan S. Primary penile venous leakage surgery with crural ligation in men with erectile dysfunction. J Urol 2008; 180: 1056-1059
- 34 Hassan AA, Hassouna MM, Elhilali MM. Long-term results of penile venous ligation for corporeal venous occlusive dysfunction. Can J Surg 1995; 38: 537-541
- 35 Rahman NU, Dean RC, Carrion R. et al. Crural ligation for primary erectile dysfunction: a case series. Journal of Urology 2005; 173: 2064-2066
- 36 Flores S, Tal R, O’Brien K. et al. Outcomes of Crural Ligation Surgery for Isolated Crural Venous Leak. J Sex Med 2011; 8: 3495-3499
- 37 Afsar H, Metin A, Sozduyar N. et al. Erectile dysfunction due to venous incompetence treated by dorsal vein ligation. Int Urol Nephrol 1992; 24: 65-68
- 38 Knoll D, Furlow WL, Benson RC. Penile Venous Ligation Surgery for the Management of Cavernosal Venous Leakage. Urol Int 1992; 49: 33-39
- 39 Haensch CA, Hilz M, Jost W. et al. S1-Guideline for Diagnosis and Treatment of Erectile Dysfunction. Fortschritte der Neurologie Psychiatrie 2019; 87: 225-233
- 40 Salonia A, Bettocchi C, Boeri L. et al. European Association of Urology Guidelines on Sexual and Reproductive Health – 2021 Update: Male Sexual Dysfunction. Eur Urol 2021; 80: 333-357
- 41 Burnett AL, Nehra A, Breau RH. et al. Erectile Dysfunction: AUA Guideline. Journal of Urology 2018; 200: 633-641
- 42 Yafi FA, Hammad MAM, Elterman D. Xialla®: a novel medical device for addressing erectile dysfunction associated with veno-occlusive dysfunction. Int J Impot Res 2024; 36: 551-552