C–H Functionalization of Quinoxalines

Abstract

As a powerful tool in modern organic synthesis, C–H functionalization offers an elegant shortcut to molecular complexity, enabling direct bond transformations without any pre-functionalization. In this connection, the C–H functionalization of quinoxalines offers a direct and efficient approach to modify the quinoxaline scaffold, a key structural motif in biologically active compounds and materials. This personal account describes the methodologies developed by our group for the C–H activation and functionalization of quinoxaline compounds.

1 Introduction

2 Difluoroalkylamidation

3 ortho C–H Alkylation

4 ortho C–H Amination

5 Conclusion

Key words

C–H functionalization - quinoxalines - ortho C–H functionalization - visible-light-induced functionalization - organophotocatalyst

Publication History

Received: 30 October 2024

Accepted after revision: 11 December 2024

Accepted Manuscript online:
11 December 2024

Article published online:
15 January 2025

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