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Synthesis
DOI: 10.1055/a-2413-7058
DOI: 10.1055/a-2413-7058
paper
Photoinduced Stereoselective Giese Addition on Coumarins
Supported by: Science and Engineering Research Board CRG/2021/006502,SERB/SCP/2022/000599Supported by: Council of Scientific and Industrial Research, India (02/0485/23/EMR-II)
Diastereoselective Giese addition on coumarin-3-carboxylate bearing a chiral auxiliary with N-hydroxyphthalimide ester to generate the corresponding alkylated adduct has been explored. Among screened chiral auxiliaries, bulkier one with appropriate steric is better for diastereoselective addition. Mechanistic studies involving Fluorescence studies, On/OFF experiments shed insight onto the plausible reaction pathway.
Publication History
Received: 01 August 2024
Accepted after revision: 11 September 2024
Accepted Manuscript online:
11 September 2024
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